Polerio was born in Lanciano, Chieti in 1548. He grew up there on the Adriatic coast. He, like many others in the aristocracy, developed a fondness for chess. He quickly became a very good player.
Soon Polerio was appearing in the Roman courts, rubbing shoulders with Leonardo, Boi, Capute and other leading masters. He quickly proved his mettle, rising in status above all others apart from Leonardo and Boi.
This was illustrated by his inclusion in the Italian traveling party to the first International Masters Tournament in Madrid. Although he did not take part in the tournament itself, he did serve as a second and a training partner to Leonardo and Boi.